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If the 24-week trial could not demonstrate significant weight loss, there is no reason to believe that longer use would produce dramatically different results

To this point we used a blunted generation of NO-pathway (NOS-blocker, L-NAME), an (over)-stimulated NO-system (NOS-substrate, L-arginine), and NO-system immobilized (in which L-NAME + L-arginine would antagonize each others responses to confirm specific NO-system involvement) (10, 45, 46)

Mouse studies reported greater fatty-acid oxidation and reduced fat-mass accumulation